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Contrary to earlier claims of complete harmlessness, recent clinical reports have linked ashwagandha to cases of clinically apparent liver injury, placing it among a growing group of herbal and dietary supplements (HDS) with recognized hepatotoxic potential [229]

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Hence, fragment library design or selection plays a foundational role in FBDD by ensuring that screened compounds are diverse, synthetically tractable, and optimised for downstream progression 16

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Clinical trial data shows otherwise